The Gut-Brain and Inflammation

This one is all about INFLAMMATION and how it affects the brain. This article focuses specifically on the links between inflammation and mental health.

Mental health issues have a huge impact on society. Some suggest that their impact is larger than any other chronic disease, including heart disease or diabetes.

I also find it particularly heartbreaking to see people suffer from mental health issues.

There are so many factors involved in complex conditions like mental health issues. Science is just starting to unravel one of these factors – inflammation.

photo of head bust print artwork
Feeling like you’re missing half your mental capacity? Inflammation might be involved.

First, we’ll go over the many links between inflammation and mental health (there are a few). 

Then, in the next post, I’ll do a follow up to may Mood Food post, with low-inflammation foods that support healthy brain function. We’ll talk about some exciting research into natural approaches – things like foods, nutrients, and lifestyle upgrades – and how these are related to better mental health.

 

NOTE: None of these are a substitute for professional medical advice. If you have any of these conditions, make sure you’re being monitored regularly by a licensed healthcare professional. Don’t discontinue mental health meds on your own, ever.

 

What is Inflammation?

The word inflammation comes from the Latin word “inflammo,” meaning “I set alight, I ignite.” [Sounds like a Prodigy song.]

Because inflammation can become harmful, it has gotten a lot of bad press lately.

However, inflammation isn’t always a bad thing. As in most areas of health, or life, it’s the balance that’s important.

Inflammation is actually a natural process that our body uses to protect against infections, irritants, and damage. The body’s actions are often more intelligent than we comprehend. Just as fever can be very healing, inflammation helps our bodies eliminate damaged cells and tissues, and helps them to repair. 

Inflammation also helps to reduce the cause of the damage, for example, by fighting the infection. Inflammation that happens in a big way, but for a short time can help the body to heal these injuries and infections.

person putting bandages on another person s knee
The swelling that accompanies inflammation is a smart way for the body to naturally immobilize an injured area so that we don’t use it quite so much for a while.

 

On the other hand, lower levels of inflammation sometimes stick around longer than necessary. This long-term “chronic” inflammation can cause damage over time.

Often, there are few, if any, signs or symptoms. It’s this chronic inflammation that is linked to many conditions including mental health, heart disease, and diabetes.

Inflammation mostly comes from our immune system’s response to infections and injuries. It also involves our blood vessels (arteries and veins) and other molecules. A few of these inflammatory molecules, or “markers,” include free radicals (oxidants), cytokines, and C-reactive protein (CRP).

So, what are the links between inflammation and mental health?

Inflammation and mental health

There are many factors linked to suboptimal mental health. One of these is inflammation.

In terms of depression, the link with inflammation was first discovered back in 1991. With respect to bipolar disorder, the link between it and immune dysfunction was proposed as far back as 1981.

NOTE: While there are many links between inflammation and mental health issues, it’s not the only connection. Others include neurotransmitter issues (e.g. serotonin, dopamine, etc.); reduction in growth factors (e.g. brain-derived neurotrophic factor, BDNF); and neuroendocrine issues (i.e. chronically increased stress hormone levels).

Research shows that inflammation may be a factor for about one-third of people with depression.

 

Link 1 – Inflammation and mental health

First of all, some mental health issues are associated with increased inflammatory markers like cytokines and CRP. For example, people with depression tend to have higher levels of cytokines. In fact, some of the inflammatory markers found in the blood are known to reach the brain.

High levels of inflammation may also inhibit recovery in people who experience mental health symptoms.

In fact, some researchers believe that levels of inflammation may actually be able to predict negative mental health outcomes.

While inflammation may be part of the cause of mental health symptoms for some people, it can go in both directions. Mental health issues may also increase some of these inflammatory markers.

Some animal studies show that stress can cause significant increase in inflammatory markers. Even people who are stressed tend to have increased levels of inflammatory markers and lower levels of anti-inflammatory markers.

 

Link #2 – Inflammatory illnesses and mental health

Inflammatory illnesses like allergic and autoimmune diseases (did you know those were inflammatory diseases?), as well as metabolic conditions (e.g. heart disease, diabetes, and obesity) are associated with higher rates of mental health symptoms.

And this link also goes both ways – people with mental health symptoms are more likely to get metabolic-related conditions.

This link between mental health symptoms and metabolic conditions has led some researchers to coin the term “mood-metabolic syndrome.” This is meant to reflect the fact that they’re linked to each other, and also that these links can go both ways.

 

medical tablets pharmacy cure
Careful with medications.

Link #3 – Inflammatory medications and mental health

People who take certain inflammatory medications are at increased risk of developing mental health symptoms. On the other hand, some medications used to treat depression (e.g. SSRIs) reduce levels of some inflammatory markers.

 

Link #4 – Inflammatory diets and mental health

There is growing evidence that people who eat a high quality diet tend to have a better sense of well-being and better mental health. This includes better moods and lower stress. Certain anti-inflammatory diets have lower rates of mental health issues.

This also means that studies show links between unhealthy eating patterns and mental health issues. Inflammatory diets (which we’ll go into more detail in other posts) are associated with higher rates of mental health symptoms.

 

Foods and moods

Evidence for a link between what we eat and how we feel is fairly new. The first studies to be published on this were as recent as 2009. This new area is called “nutritional psychiatry.”

The relationships between foods and mental health are complex, and we’re just starting to understand them. While many studies show a link, all of them don’t.

As an example, one study concluded:

“Our data support the hypothesis that high dietary quality is associated with good emotional well-being.”(Meegan et. al, 2017)

 

What foods are associated with worse moods? These not-so-healthy dietary patterns include higher intakes of:

  • Saturated fat and processed meats;
  • Refined sugars and starches; and
  • Fried and processed foods.

 

Not surprised?

People who eat this way tend to report more mental health symptoms than those who eat a more health-promoting diet. And, several recent studies consider poor eating habits to be a risk factor for some mental health issues.

 

Not surprisingly, these not-so-healthy foods are also linked with higher inflammatory markers like CRP. And several studies show that improving the diet can reduce levels of CRP.

In fact, some studies show that the higher the “inflammatory factor” of the diet, the higher the risk for mental health issues.

One dietary pattern that’s been studied a lot is the Mediterranean diet. This diet includes a lot of vegetables, fruit, whole grains, legumes, fish, and olive oil. It also contains a lot of nutrients and fibre. Eating a Mediterranean-style diet is associated with lower levels of inflammatory markers and a reduced risk of mental health issues.

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Olive oil, fish, herbs, lemon, wine and getting lots of veggies are Mediterranean hallmarks.

This complex association between food and mental health can also go both ways. Mental health symptoms can also influence appetite and food choices. And it’s likely that other factors such as obesity, exercise, food insecurity, and use of alcohol and tobacco are probably involved as well.

We don’t know exactly how these eating patterns affect mental health – inflammation is definitely one possibility. Nutrition can impact how our immune system functions, and this can affect levels of inflammation, and mental health issues. It could also be through the effects of the nutrients themselves, and even directly through the digestive system (microbiota-gut-brain axis).

 

Better foods for better moods

In fact, it’s not just “associations.” A recent clinical study found that when people start eating a healthier diet, they can actually reduce some of their mental health symptoms!

This study is particularly interesting. It’s called the SMILES trial.

The SMILES trial

What makes the results from the SMILES trial strong is that it was an actual experiment. It didn’t just ask people what they ate, measured their inflammatory markers, and what their symptoms were. It was “interventional” – people agreed to actually change the way they ate!

 

The researchers say:

 

“…this is the first RCT [randomized control trial] to explicitly seek to answer the question: If I improve my diet, will my mental health improve?”(Jacka et. al, 2017)

 

Here’s how it worked:

The SMILES trial recruited 67 people with with depression and poor dietary quality to a trial for 12-weeks. These were people who reported a high intake of sweets, processed meats, and salty snacks; and a low intake of vegetables, fruits, lean protein, and dietary fibre.

 

Half of them were asked to:

  • Eat more vegetables, whole grains, fruit, legumes, low-fat unsweetened dairy, raw and unsalted nuts, fish, lean red meat, chicken, eggs and olive oil; and
  • Eat less sweets, refined grains, fried food, fast food, processed meats and sugary drinks; and,
  • Drink no more than 2 glasses of wine per day (with meals, preferably red wine).

 

This half of the participants who upgraded their diet were also given seven professional nutrition counselling sessions.

 

The other half of the people in the SMILES trial were given social support. They were “befriended” and discussed sports or news, or played cards or board games. There was no nutrition support, nor any dietary recommendations given to people in this group.

 

The researchers found that in 12-weeks the people who improved their diet actually also improved some mental health symptoms!

They said:

“We report significant reductions in depression symptoms as a result of this intervention… The results of this trial suggest that improving one’s diet according to current recommendations targeting depression may be a useful and accessible strategy for addressing depression in both the general population and in clinical settings.”(Jacka et. al, 2017)

 

It would be great for other, larger trials to confirm these results. In the meantime, eating a more health-promoting diet is helpful for so many conditions, not just mental health conditions!

 

What do you think of these results?

It seems inflammation is one of several factors that is linked with mental health and mood issues. It may be a factor for up to one-third of people who suffer from these.

The link between inflammation and mental health issues is thought to go both ways – inflammation can contribute to mental health and mood issues, and vice versa.

So, do you think we would be a happier society overall, and that teens could have less anxiety, if we all ate a little better?

I love to hear from you!

xox

Dana

 

Next post: Better Nutrition for Better Moods

 

About Dana Green Remedios

Holistic Nutritionist

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